Table 1 Clinical (at time of scan) and Doppler-measured hemodynamic parameters in both study group (1a). Clinical and Doppler- measured hemodynamic parameters before and after PRBCs-transfusion in the anemic group (1b)

Table (1a)

Non-anemic control group

(n = 36)

Anemic group

(n = 36)

P

Postnatal age at time of examination (days)

Min.–Max.

21–57

21–59

0.002^*

Mean ± SD.

25.5 ± 6.1

30.4 ± 8.6

Median (IQR)

24 (22–27)

29.5 (23.5–33.5)

Hb (g/dl)

Min.–Max.

9.8–17

5.5–9.3

< 0.001^*

Mean ± SD.

12.1 ± 1.4

7.4 ± 0.8

Median (IQR)

11.9 (11.1–12.8)

7.6 (7.1–7.9)

HCT (%)

Min.–Max.

30.2–43

10–25.3

< 0.001^*

Mean ± SD.

33.8 ± 2.9

20.6 ± 2.8

Median (IQR)

33.3 (31.6–34.8)

21.1 (19.5–22.6)

SBP (mmHg)

Min.–Max.

60–86

52–86

0.164

Mean ± SD.

70.7 ± 5.5

68.6 ± 7.1

Median (IQR)

70.5 (67–74)

69.5 (63–73.5)

DBP (mmHg)

Min.–Max.

40–55

27–55

0.260

Mean ± SD.

49.1 ± 4.3

47.1 ± 6.3

Median (IQR)

50 (48–52)

49 (42–52)

MABP (mmHg)

Min.–Max.

47–66

35–66

0.286

Mean ± SD.

56.1 ± 4.9

54.2 ± 6.6

Median (IQR)

56 (53–60)

55.5 (49–59.5)

Resting HR (B/min)

Min.–Max.

115–165

130–186

< 0.001^*

Mean ± SD.

145.5 ± 12.6

160.4 ± 15.1

Median (IQR)

147 (136–155)

162.5 (145–170)

Stroke volume (ml/kg)

Min.–Max.

1.03–2.42

1.34–3.33

0.017^*

Mean ± SD.

1.56 ± 0.33

2.12 ± 0.58

Median (IQR)

1.52 (1.32–1.82)

2.06 (1.65–2.55)

LVO (ml/kg/min)

Min.–Max.

140–322

199–570

< 0.001^*

Mean ± SD.

226.23 ± 42.32

328.59 ± 87.01

Median (IQR)

221.8 (190.5–258.5)

315 (263.9–377.35)

ACA

PSV (cm/sec.)

Min.–Max.

26–58

22.3–76

0.001^*

Mean ± SD.

36.92 ± 7.39

45.91 ± 12.16

Median (IQR)

35 (33.15–40.25)

45.15 (35.9–53.15)

EDV (cm/sec.)

Min.–Max.

3.7–14

3–23

0.358

Mean ± SD.

7.09 ± 2.35

8.43 ± 4.4

Median (IQR)

6.55 (5.6–7.65)

6.85 (5.7–10.4)

RI

Min.–Max.

0.71–0.87

0.67–0.94

0.375

Mean ± SD.

0.81 ± 0.05

0.82 ± 0.07

Median (IQR)

0.81 (0.77–0.86)

0.82 (0.79–0.88)

Renal artery

PSV (cm/sec.)

Min.–Max.

20–59

23–63

0.535

Mean ± SD.

37.63 ± 8.49

38.91 ± 8.92

Median (IQR)

37.5 (33–42)

38.35 (33–44.5)

EDV (cm/sec.)

Min.–Max.

3.7–11.5

3–10

0.241

Mean ± SD.

6.29 ± 1.94

5.76 ± 1.64

Median (IQR)

6.15 (5–7.15)

5.7 (4.5–6.9)

RI

Min.–Max.

0.72–0.9

0.73–0.91

0.058

Mean ± SD.

0.83 ± 0.05

0.85 ± 0.04

Median (IQR)

0.83 (0.81–0.86)

0.86 (0.83–0.88)

Coeliac artery

PSV (cm/sec.)

Min.–Max.

47–94

49–115

0.478

Mean ± SD.

67.07 ± 11.27

71.4 ± 17.45

Median (IQR)

65 (60–73.6)

67 (59.5–81.35)

EDV (cm/sec.)

Min.–Max.

7–23.5

5.7–34.6

0.272

Mean ± SD.

14.15 ± 4.05

13.69 ± 6.24

Median (IQR)

13.45 (11–17)

12.25 (9–16.5)

RI

Min.–Max.

0.67–0.89

0.65–0.9

0.351

Mean ± SD.

0.79 ± 0.05

0.8 ± 0.07

Median (IQR)

0.79 (0.76–0.83)

0.81 (0.76–0.86)

Table (1b)

Before PRBCs

(n = 36)

After PRBCs

(n = 36)

P

Hb (g/dl)

Min.–Max.

5.5–9.3

9.0–13.0

< 0.001^*

Mean ± SD.

7.4 ± 0.8

10.6 ± 0.9

Median (IQR)

7.6 (7.1–7.9)

10.4 (10.0–10.9)

Hct (%)

Min.–Max.

10–25.3

26.6–39.0

< 0.001^*

Mean ± SD.

20.6 ± 2.8

29.7 ± 2.8

Median (IQR)

21.1 (19.5–22.6)

29.0 (28.0–30.0)

SBP (mmHg)

Min.–Max.

52–86

55.0–76.0

0.05^*

Mean ± SD.

68.6 ± 7.1

67.3 ± 6.1

Median (IQR)

69.5 (63–73.5)

68.0 (61.5–72.5)

DBP (mmHg)

Min.–Max.

27–55

32.0–55.0

0.061

Mean ± SD.

47.1 ± 6.3

46.3 ± 5.2

Median (IQR)

49 (42–52)

47.5 (43.5–50.0)

MABP (mmHg)

Min.–Max.

35–66

40.0–61.0

0.119

Mean ± SD.

54.2 ± 6.6

53.2 ± 5.3

Median (IQR)

55.5 (49–59.5)

53.5 (49.5–58.0)

HR (B/min)

Min.–Max.

130–186

130.0–185.0

< 0.001^*

Mean ± SD.

160.4 ± 15.1

148.6 ± 12.9

Median (IQR)

162.5 (145–170)

147.5 (140.0–158.0)

Stroke volume (ml/kg)

Min.–Max.

1.34–3.33

1.0–2.77

< 0.001^*

Mean ± SD.

2.12 ± 0.58

1.73 ± 0.44

Median (IQR)

2.06 (1.65–2.55)

1.64 (1.39–2.12)

LVO(ml/kg/min)

Min.–Max.

199–570

154–439.8

< 0.001^*

Mean ± SD.

328.59 ± 87.01

257.24 ± 63.12

Median (IQR)

315 (263.9–377.35)

245.25 (218.2–306)

ACA

PSV (cm /Sec)

Min.–Max.

22.3–76

22.3–55.3

< 0.001^*

Mean ± SD.

45.91 ± 12.16

34.11 ± 7.72

Median (IQR)

45.15 (35.9–53.15)

32.8 (28–37.25)

EDV(cm /Sec)

Min.–Max.

3–23

3.6–12.5

0.05^*

Mean ± SD.

8.43 ± 4.4

6.91 ± 2.14

Median (IQR)

6.85 (5.7–10.4)

6.8 (5.25–8.45)

RI

Min.–Max.

0.67–0.94

0.7– 0.92

0.101

Mean ± SD.

0.82 ± 0.07

0.8 ± 0.05

Median (IQR)

0.82 (0.79–0.88)

0.8 (0.78 − 0.83)

Renal artery (RA)

PSV(cm /Sec)

Min.–Max.

23–63

19.5–55

< 0.001^*

Mean ± SD.

38.91 ± 8.92

32.52 ± 7.26

Median (IQR)

38.35 (33–44.5)

32.5 (28.5–36.5)

EDV(cm /Sec)

Min.–Max.

3–10

3–11

0.702

Mean ± SD.

5.76 ± 1.64

5.84 ± 1.67

Median (IQR)

5.7 (4.5–6.9)

5.6 (5–7)

RI

Min.–Max.

0.73–0.91

0.7–0.91

0.011^*

Mean ± SD.

0.85 ± 0.04

0.82 ± 0.05

Median (IQR)

0.86 (0.83–0.88)

0.83 (0.79–0.85)

Coeliac artery (CA)

PSV(cm /Sec)

Min.–Max.

49–115

44–112

0.122

Mean ± SD.

71.4 ± 17.45

66.42 ± 15.59

Median (IQR)

67 (59.5–81.35)

66.35 (57.5–72.5)

EDV(cm /Sec)

Min.–Max.

5.7–34.6

6–22

0.330

Mean ± SD.

13.69 ± 6.24

12.28 ± 3.93

Median (IQR)

12.25 (9–16.5)

12 (10–14.5)

RI

Min.–Max.

0.65–0.9

0.61–0.92

0.609

Mean ± SD.

0.8 ± 0.07

0.81 ± 0.06

Median (IQR)

0.81 (0.76–0.86)

0.82 (0.79–0.86)