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Table 3 Biochemical data of NF1 patients and controls

From: Neurofibromatosis type I (NF1) and bone involvement in a pediatric setting: insights from FGF23 levels

Laboratory data

NF1 mean ± SDa/median(IQRb)

Controls mean ± SD/median(IQR)

P-value

Serum-corrected Calcium (mg/dL, nv 8.5–10.5)

9.27 ± 0.23

9.16 ± 0.43

ns*

Phosphorus (mg/dL)

4.56 ± 0.54

4.61 ± 0.49

ns*

Alkaline phosphatase (IU/L, nv 62–100)

184.6 ± 88.2

198.8 ± 44.1

ns*

Alkaline phosphatase SDa

-0.95 (-1.34; -0.44)

-0.76 (-1.43; -0.20)

ns°

25OHvitDc (ng/dL)

30.6 ± 9.9

24.5 ± 8.2

ns*

TmP/GFRd

1.63 ± 0.30

1.56 ± 0.32

ns*

FGF23e intact (pg/mL)

41.6 ± 13.9

49.3 ± 12.2

ns*

FGF23e c-terminal (RUf/mL)

59.2 (48; 73.1)

62.1 (56.2; 72.2)

ns°

αKlotho (pg/mL)

2132.2 (1678.6; 2973.6)

2578.1 (2182.6; 3228.5)

ns°

  1. *T-Student test
  2. °Mann–Whitney test
  3. aSD Standard Deviation
  4. bIQR Inter-Quartile range
  5. c25OHvitD 25-hydroxyvitamin D
  6. dTmP/GFR Renal tubular maximum reabsorption of phosphate/glomerular filtration rate
  7. eFGF23 Fibroblast Growth Factor 23
  8. fRU Relative Units