Table 3 Prediction of pathological cerebral resonance imaging in preterm infants complicated or not by intraventricular hemorrhage based on urine Activin A concentrations (pg/mL)
Time-point | cut-off (pg/mL) | Sensitivity (CI5–95%) | Specificity (CI5–95%) | PPV (CI5–95%) | NPV (CI5–95%) | AUC (CI5–95%) |
|---|---|---|---|---|---|---|
First void, T0 | > 0.08 | 65(43–87) | 87(66–97) | 83(63–94) | 71(58–82) | 0.74(0.59–0.86) |
24 h, T1 | > 0.04 | 78(56–93) | 83(61–95) | 82(64–92) | 79(63–89) | 0.83(0.69–0.92) |
48 h, T2 | > 0.08 | 74(52–90) | 100(85–100) | 100 | 79(66–88) | 0.93(0.82–0.99) |
72 h, T3 | > 0.05 | 74(52–90) | 91(72–99) | 90(69–97) | 78(64–88) | 0.83(0.69–0.92) |
96 h, T4 | > 0.09 | 65(43–84) | 100(85–100) | 100 | 74(62–83) | 0.86(0.72-.094) |