Amino acid variants in the HLA-DQA1 and HLA-DQB1 molecules explain the major association of variants with relapse status in pediatric patients with steroid-sensitive nephrotic syndrome

Table 5 Correlation of genotypes with relapse frequency and infections at relapse in SDNS/FRNS patients

SNP	Clinical characteristics	Genotype frequency			P	Dominant model -P value	OR (95% CI)
rs1047989 (A)	Recurrence frequency (n/semiannual)	AA	AG	GG	0.67	0.56	0.60(0.17,1.96)
	2	27	23	8
	>2	28	25	5
	Number of infections at relapse	AA	AG	GG	0.045	0.02	6.79(1.29, 168.52)
	≤ 2	16	15	1
	>2	39	28	17
2:171713702 (T)	Recurrence frequency (n/semiannual)	TT	CT	CC	0.02	0.02	2.59(1.21, 5.74)
	2	0	42	16
	>2	0	29	29
	Number of infections at relapse	TT	CT	CC	0.12	0.17	2.13(0.84, 6.01)
	≤ 2	0	25	7
	>2	0	46	28
rs1049123 (T)	Recurrence frequency (n/semiannual)	TT	CT	CC	0.42	0.42	0.56(0.18,1.66)
	2	0	6	52
	>2	0	10	48
	Number of infections at relapse	TT	CT	CC	0.77	0.77	1.24(0.35,3.83)
	≤ 2	0	5	27
	>2	0	11	73
rs9273471 (A)	Recurrence frequency (n/semiannual)	AA	AG	GG	0.97	1	1.10(0.46, 2.65)
	2	14	31	13
	>2	14	30	14
	Number of infections at relapse	AA	AG	GG	0.07	0.07	3.03 (1.04,11.33)
	< median	7	32	4
	> median	21	37	26
DQB1:06:02	Recurrence frequency (n/semiannual)	DQB1:06:02 /DQB106:02	DQB1:06:02 /Other	Other /Other	0.50	0.62	0.35(0.01,3.14)
	2	0	0	58
	>2	0	2	56
	Number of infections at relapse	DQB1:06:02 /DQB106:02	DQB1:06:02 /Other	Other /Other	0.54	0.62	0.35(0.01,3.14)
	≤ 2	0	0	32
	>2	0	2	56

ISSN: 1824-7288