Table 4 Genotype distributions and genetic model analysis for risk variants

rs117962550 (A)

Genotype

AA

0(0.00)

0(0.00)

0.1901

-

AC

19(9.22)

27(6.21)

CC

187(90.78)

408(93.79)

Recessive model

AA vs. (AC + CC)

0(0.00)/206(100.00)

0(0.00)/435(100.00)

-

-

Dominant model

(AA + AC) vs. CC

19(9.22)/187(90.78)

27 (6.21)/408(93.79)

1.69E-01

1.54(0.82, 2.82)

Additive model

AA vs. AC vs. CC

0(0.00)/19(9.22)/187(90.78)

0(0.00)/27 (6.21)/408(93.79)

1.70E-01

1.54(0.82,2.82)

rs1464545187 (A)

Genotype

AA

0(0.00)

2(0.46)

0.40

-

AG

42(20.39)

75(17.24)

GG

164(79.61)

358(82.30)

Recessive model

AA vs. (AG + GG)

0(0.00)/206(100.00)

2(0.46)/433(99.54)

0.54

0.42(0.003,5.19)

Dominant model

(AA + AG) vs. GG

42(20.39)/164(79.61)

77(17.70)/358(82.30)

4.14E-01

1.19(0.78,1.80)

Additive model

AA vs. AG vs. GG

0(0.00)/42(20.39)/164(79.61)

2(0.46)/75(17.24)/358(82.30)

0.50

1.15(0.76,1.72)

rs1047989 (A)

Genotype

AA

92(44.66)

113(25.98)

2.42E-06

-

AG

89(43.20)

220(50.57)

GG

25(12.14)

102(23.45)

Recessive model

AA vs. (AG + GG)

92(44.66)/114(55.34)

102(23.45)/333(76.55)

7.53E-08

2.63(1.85,3.75)

Dominant model

(AA + AG) vs. GG

181(87.86)/25(12.14)

322(74.02)/113(25.98)

1.01E-04

2.54(1.61,4.14)

Additive model

AA vs. AG vs. GG

92(44.66)/89(43.20)/25(12.14)

113(25.98)/220(50.57)/102(23.45)

1.32E-08

2.06(1.61,2.66)

2:171713702(T)

Genotype

TT

0(0.00)

0(0.00)

2.2E-16

-

CT

135(65.53)

6(1.38)

CC

71(34.47)

429(98.62)

Recessive model

TT vs. (CT + CC)

0(0.00)/206(100.00)

0(0.00)/435(100.00)

-

-

Dominant model

(TT + CT) vs. CC

135(65.53)/71(34.47)

6(1.38)/429(98.62)

2.14E-29

135.95(62.68,356.99)

Additive model

TT vs. CT vs. CC

0(0.00)/135(65.53)/71(34.47)

0(0.00)/6(1.38)/429(98.62)

2.14E-29

135.95(62.68,356.99)

rs1049123 (T)

Genotype

TT

0(0.00)

1(0.23)

9.75E-05

-

CT

36(17.48)

30(6.90)

CC

170(82.52)

404(92.87)

Recessive model

TT vs. (CT + CC)

0(0.00)/206(100.00)

1(0.23)/434(99.77)

0.8235151

0.70(0.004,13.21)

Dominant model

(TT + CT) vs. CC

36(17.48)/170(82.52)

31(7.13)/404(92.87)

1.04E-04

2.76(1.65,4.63)

Additive model

TT vs. CT vs. CC

0(0.00)/36(17.48)/170(82.52)

1(0.23)/30(6.90)/404(92.87)

2.07E-04

2.58(1.57,4.27)

rs9273471 (A)

Genotype

AA

51(24.76)

64(14.71)

8.95E-06

-

AG

104(50.49)

182(41.84)

GG

51(24.76)

189(43.45)

Recessive model

AA vs. (AG + GG)

51(24.76)/155(75.24)

64(14.71)/371(85.29)

2.18E-03

1.91(1.26,2.88)

Dominant model

(AA + AG) vs. GG

155(75.24)/51(24.76)

246(56.55)/189(43.45)

6.60E-06

2.34(1.62,3.40)

Additive model

AA vs. AG vs. GG

51(24.76)/104(50.49)/51(24.76)

64(14.71)/182(41.84)/189(43.45)

3.07E-06

1.75(1.39,2.22)

HLA-DQB1*06:02

Genotype

06:02/06:02

1(0.49)

4(3.22)

0.02

-

06:02/Other

6(2.91)

35(8.05)

Other/other

199(96.60)

396(91.03)