Table 3 Candidate SNPs and HLA-DQB1*06:02 associated with Chinese SSNS

Gene

ALPG

ANKRD36

HLA-DQB1

Frequency of risk allele in SSNSWR (n = 90)

9(5.00%)

26(14.44%)

5(2.78)

Frequency of risk allele in controls (n = 435)

27(3.10%)

79(9.08)%

39(4.48%)

P value

0.29

0.04

0.40

OR (95% CI)

1.64(0.76,3.56)

1.69(1.05,2.72)

0.61(0.24,1.57)

Candidate variants

rs1047989 (A)

2:171713702 (T)

rs1049123 (T)

rs9273471 (A)

HLA-DQB1*06:02

Gene

HLA-DQA1

GAD1

HLA-DQB1

HLA-DQB1

HLA-DQB1

Frequency of risk allele in SDNS/FRNS (n = 116)

158(68.10%)

71(30.60%)

16(6.90%)

117(50.43%)

2(0.86%)

Frequency of risk allele in controls (n = 435)

424(48.74%)

6(0.69%)

32(3.68%)

310(35.63%)

39(4.48%)

P value

2.26E-07

2.2E-16

0.05

5.45E-05

0.01

OR (95% CI)

2.25(1.65,3.05)

63.50(27.14,148.59)

1.94(1.05,3.60)

1.84(1.37,2.46)

0.19(0.04,0.77)