Table 2 Association between antenatal corticosteroids and neonatal outcomes among very preterm infants born to mothers with hypertensive disorders of pregnancy
ACS (n = 3806) N/(%) | No ACS (n = 776) N/(%) | P-value | Crude OR (95% CI) | aORa (95% CI) | |
|---|---|---|---|---|---|
Primary outcome | |||||
Surfactant and/or IMV within 72 h of life | 2579 (67.8) | 595 (76.7) | < 0.0001 | 0.61 (0.50–0.74) | 0.60 (0.49–0.74) |
Secondary outcomes | |||||
Death | 347 (9.1) | 114 (14.7) | < 0.0001 | 0.53 (0.42–0.68) | 0.54 (0.42–0.70) |
Surfactant within 72 h of life | 2335 (61.4) | 509 (65.6) | 0.026 | 0.77 (0.64–0.92) | 0.77 (0.64–0.93) |
IMV within 72 h of life | 1450 (38.1) | 402 (51.8) | < 0.0001 | 0.58 (0.49–0.69) | 0.59 (0.49–0.71) |
Combined surfactant and IMV use within 72 h of life | 1206 (31.7) | 316 (40.7) | < 0.0001 | 0.66 (0.55–0.78) | 0.69 (0.57–0.82) |
Moderate or severe BPD | 1402/3787 (37.0) | 374/771 (48.5) | < 0.0001 | 0.61 (0.52–0.72) | 0.61 (0.51–0.73) |
IVH (Grade III or IV) | 184/3457 (5.3) | 45/675 (6.7) | 0.163 | 0.75 (0.52–1.08) | 0.78 (0.53–1.14) |
PVL | 96/3441 (2.8) | 26/673 (3.9) | 0.133 | 0.76 (0.46–1.24) | 0.86 (0.51–1.45) |
NEC (Stage II or above) | 183 (4.8) | 34 (4.4) | 0.610 | 1.10 (0.73–1.66) | 1.06 (0.70–1.62) |
Early-onset sepsis | 29 (0.8) | 7 (0.9) | 0.687 | 0.69 (0.30–1.60) | 0.58 (0.24–1.38) |
Sepsis | 335 (8.8) | 73 (9.4) | 0.590 | 0.92 (0.69–1.22) | 0.95 (0.70–1.27) |