Table 4 Risk factors for the progression of SRNS to CKD5
Variables | Univariate Cox regression | Multivariate Cox regression | ||
|---|---|---|---|---|
HR (95%CI) | P-value | HR (95%CI) | P-value | |
Steroid resistant-style (reference, uncertain) | ||||
I-SRNS | 0.123 (0.014, 1.069) | 0.057 | ||
S-SRNS | 0.011 (0.001, 0.206) | 0.002 | 0.125 (0.003, 5.966) | 0.291 |
Age of onset | 0.999 (0.987, 1.012) | 0.899 | ||
Sex (reference, male) | ||||
Female | 1.748 (0.674, 4.534) | 0.251 | ||
Nation (reference, Han) | ||||
Zhuang | 0.620 (0.234, 1.643) | 0.336 | ||
Others | 0.000 (0.000, Inf ) | 0.998 | ||
Family history (reference, no) | ||||
Yes | 7.320 (2.582, 20.756) | < 0.001 | 2.046 (0.344, 12.169) | 0.431 |
Extra-kidney manifestations (reference, no) | ||||
Yes | 1.817 (0.525, 6.295) | 0.346 | ||
24-hour urinary protein | 1.000 (0.999, 1.000) | 0.124 | ||
Scr | 1.003 (1.001, 1.004) | < 0.001 | 1.003 (1.000, 1.007) | 0.038 |
eGFR | 0.986 (0.976, 0.996) | 0.005 | 1.001 (0.996, 1.007) | 0.624 |
Hypertension (reference, no) | ||||
Yes | 1.929 (0.728, 5.110) | 0.186 | ||
Kidney biopsy (reference, MCD) | ||||
FSGS | 4.205 (0.888, 19.919) | 0.070 | ||
MsPGN | 5.196 (0.725, 37.233) | 0.101 | ||
MN | 10.456 (0.905, 120.788) | 0.060 | ||
DMS | 21.715 (1.929, 244.396) | 0.013 | 0.209 (0.002, 28.620) | 0.533 |
Hematuria (reference, no) | ||||
Yes | 2.243 (0.885, 5.682) | 0.089 | ||
Response to immune therapy (reference, no use) | ||||
Valid | 0.133 (0.018, 0.961) | 0.046 | 0.320 (0.011, 9.095) | 0.504 |
Invalid | 1.575 (0.355, 6.996) | 0.550 | ||
AKI (reference, no) | ||||
Yes | 4.419 (1.669, 11.703) | 0.003 | 4.829 (1.113, 20.947) | 0.035 |