Skip to main content

Table 2 Qualitative synthesis results of differential small molecule metabolites between BPD and no BPD

From: Analysis of variable metabolites in preterm infants with bronchopulmonary dysplasia: a systematic review and meta-analysis

 

Differential small molecule metabolites name

Sample

Patients predisposed to BPD

Patients not predisposed to BPD

Concentration Trend

upward

downward

upward

downward

exhaled breath condensate

Maleimide, Octadecanol

Urea, Pyroglutamic acid, Valine, Triethanolamine, Histidine, Alanine, Ornithine, Serine

  

Dried blood spot

three carnitines (C0, C2, and C6:1), glutamate, ornithine, phenylalanine, methionine, hydroxypalmitoylcarnitine

threonine, arginine, methionine, glutamine, glycine, proline, tryptophan, piperazine, Citrulline, alanine, glutamate, tyrosine, propionylcarnitine, free

carnitine, acetylcarnitine, hydroxybutyrylcarnitine, and median-chain acylcarnitines (C5:C10)

  

Stool

 

Acetic Acid

  

tracheal aspirate

Histidine, glutamate, citrulline, glycine, isoleucine, Serine, acylcarnitines C16-OH, C14:1-OH, C10:1, C14:2-OH, C18:1-OH, C12:1, PCaaC24:0, PCaaC26:0, PCaaC38:5, PCaeC38:1, PCaeC36:3, PCaeC42:4, PCaeC44:5, lysoPCaC16:1, lysoPCaC28:1, lysoPCaC26:0, lysoPCaC14:0, lysoPCaC20:4, sn-glycerol 3-phosphoethanolamine, Sphingosine 1-phosphate, ceramides C14:0, ceramides C22:0, monohexosylceramide C18:1, monohexosylceramide C22:0, monohexosylceramide C26:0, sphingomyelin C18:0, sphingomyelin C20:0

 

polyunsaturated fatty acid, plasmalogens, Symmetric dimethylarginine

 

Urinary

canine uric acid, thymine, alanine, betaine, lactate, taurine, trimethylamine-N-oxide, myoinositol, tyrosine, proline, Fumaric acid, 2-oxoisocaproic acid, 2-hydroxybutyric acid, acylcarnitines C0, acylcarnitines C2, acylcarnitines C4-OH, acylcarnitines C4, acylcarnitines C5, acylcarnitines C5:1DC

trehalose, tartaric acid, trimethylamine-N-oxides, lactate, glycine, gluconate,

serotonin, 5-hydroxyl indoleacetic acid, indoxyl sulfates, allantoin, homocitrulline

  

Umbilical cord blood

choline

phosphatidylcholines, sphingomyelins

  

Amniotic Fluid

leucinic acid, 4-Hydroxy3-methylbenzoic acid, 2-hydroxy caprylic acid, 3-oxododecanoic acid, sulphated steroid

S-adenosylmethionine, aminoacid chains

3b,16a-Dihydroxyandrostenone sulfate

 
  1. Note: C0, Carnitine; C2, Acetylcarnitine; C6:1, Hexenoylcarnitine; C16-OH, Hydroxyhexadecanoylcarnitine; C14:1-OH, Hydroxytetradecenoylcarnitine; C10:1, Decenoylcarnitine; C14:2-OH, Hydroxytetradecadienylcarnitine; C18:1-OH, Hydroxyoctadecenoylcarnitine; C12:1, Dodecenoylcarnitine; PCaa, Phosphatidylcholine diacyl; PCae, Phosphatidylcholine acyl-alkyl; lysoPCa, Lysophosphatidylcholine acyl; C24:0, Lignoceroylcarnitine; C26:0, Cerotoylcarnitine; C38:5, Hexatriacontapentaenoylcarnitine; C38:1, Octatriacontenoylcarnitine; C36:3, triacylcarnitine; C42:4, tetraeicosatetraenoylcarnitine; C44:5, pentacosapentaenoylcarnitine; C16:1, hexadecenoylcarnitine; C28:1, octacosanoylcarnitine; C14:0, tetradecanoylcarnitine; C20:4, eicosatetraenoylcarnitine; C22:0, docosanoylcarnitine; C18:1, octadecenoylcarnitine; C4-OH, 4-hydroxybutyrylcarnitine; C4, butyrylcarnitine; C5, isovalerylcarnitine; C10, decanoylcarnitine; C5:1DC, glutarylcarnitine
Back to article page

Italian Journal of Pediatrics

ISSN: 1824-7288

Contact us