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Table 2 Comparison of treatment information and complications between the response group and non-response group

From: The association of gene polymorphisms of adenosine and dopamine receptors with the response to caffeine citrate treatment in infants with apnea of prematurity: a prospective nested case-control study

Variables

Total (n = 221)

Non-response group (n = 61)

Response group (n = 160)

Z/X2

P

No oxygen therapy at admission, n (%)

29 (13.1)

9 (14.8)

20 (12.5)

0.197

0.657

Noninvasive mechanical ventilation at admission, n (%)

157 (71.0)

39 (63.9)

118 (73.8)

2.068

0.150

Invasive mechanical ventilation at admission n (%)

35 (15.8)

13 (21.3)

22 (13.8)

1.894

0.169

Total oxygen supplementation time, M (Q1, Q3), days

19.0 (10.6, 38.6)

39.5 (22.6, 52.8)

16.0 (8.9, 28.3)

-6.273

< 0.001

Noninvasive mechanical ventilation time, M (Q1, Q3), days

13.4 (6.4, 29.4)

30.3 (11.4, 44.5)

10.2 (5.1, 19.2)

-5.539

< 0.001

Invasive mechanical ventilation, n (%)

40 (18.1)

18 (11.3)

22 (36.1)

18.346

< 0.001

Invasive mechanical ventilation time, M (Q1, Q3), days

2.9 (1.5, 5.7)

3.5 (2.1, 7.6)

2.5 (0.9, 4.2)

-2.066

0.039

High-frequency ventilation mechanical time, M (Q1, Q3), days

1.8 (0.5, 4.0)

1.7 (0.7, 5.1)

2.0 (0.1, 3.6)

-1.043

0.297

Re-intubations after extubation, n (%)

5 (2.3)

4 (6.6)

1 (0.6)

4.602

0.032a

Caffeine citrate average Maintenance dose, M (Q1, Q3), mg/kg/d

5.1 (5.0, 5.5)

5.7 (5.0, 9.8)

5.0b

-9.447

< 0.001

Caffeine citrate duration, M (Q1, Q3), days

15.5 (9.0, 28.0)

30.5 (17.0, 43.0)

12.5 (8, 21)

-6.147

< 0.001

BPD, n (%)

79 (35.7)

44 (72.1)

35 (21.9)

48.563

< 0.001

Mild BPD, n (%)

35 (15.8)

22 (36.1)

13 (8.13)

21.146

< 0.001

Moderate and severe BPD, n (%)

44 (19.9)

22 (36.1)

22 (13.8)

13.792

< 0.001

NEC, n (%)

5 (2.3)

1 (1.6)

4 (2.5)

0.000

1.000a

ROP, n (%)

91 (41.2)

40 (65.6)

51 (31.9)

20.705

< 0.001

Brain injury, n (%)

33 (14.9)

14 (23.0)

19 (11.9)

4.265

0.039

Death, n (%)

1 (0.5)

1 (1.6)

0

0.252

0.616a

Length of hospital stay, M (Q1, Q3), days

30.0 (21.0, 47.0)

50.5 (33.8, 65.0)

27 (20, 35)

-5.981

< 0.001

  1. a: Continuity correction chi square test
  2. b: The caffeine citrate average maintenance dose in the response group were 5.0 mg/kg/d
  3. BPD: bronchopulmonary dysplasia, NEC: necrotizing enterocolitis, ROP: retinopathy of prematurity