Table 1 Baseline clinical characteristics of the training and validation sets

Age, (months) (%)

19.00 [11.00, 34.00]

20.00 [11.30, 35.00]

17.00 [9.29, 33.00]

19.00 [11.77, 35.00]

0.443

Sex (%)

male

230 (62.0)

120 (63.5)

76 (59.8)

34 (61.8)

0.806

female

141 (38.0)

69 (36.5)

51 (40.2)

21 (38.2)

Clinical Information

Fever duration (days)

6.00 [5.00, 7.00]

5.00 [5.00, 7.00]

6.00 [5.00, 7.00]

6.00 [5.00, 7.00]

0.376

Initial IVIG resistance(%)

+

37 (10.0)

21 (11.1)

11 (8.7)

5 (9.1)

0.754

-

334 (90.0)

168 (88.9)

116 ( 91.3)

50 (90.9)

KD subtypes, No. (%)

cKD

332 (89.5)

157 (90.8)

127 (88.8)

48 (87.3)

0.802

iKD

39 (10.5)

16 (9.2)

16 (11.2)

7 (12.7)

CALs status

CALs progressed

Yes

65 (17.5)

40 (21.2)

18 (14.2)

7 (12.7)

0.166

No

306 (82.5)

149 (78.8)

109 (85.8)

48 ( 87.3)

Baseline Zmax

2.63 [2.31, 3.48]

2.70 [2.30, 3.53]

2.58 [2.32, 3.34]

2.59 [2.28, 3.50]

0.845

NCAI

1

189 (50.9)

91 (48.1)

73 (57.5)

25 (45.5)

0.389

2

96 (25.9)

52 (27.5)

28 (22.0)

16 (29.1)

3

57 (15.4)

32 (16.9)

14 (11.0)

11 (20.0)

4

29 (7.8)

14 (7.4)

12 (9.4)

3 (5.5)

Laboratory Examination

WBC (*10⁹/L)

15.90 [13.06, 19.68]

16.32 [13.79, 19.70]

15.41 [12.73, 19.13]

14.92 [11.71, 19.88]

0.115

N%

0.69 [0.60, 0.79]

0.69 [0.60, 0.79]

0.68 [0.61, 0.79]

0.68 [0.59, 0.75]

0.544

Hb (g/L)

115.71 (12.82)

115.93 (13.13)

115.43 (12.85)

115.64 (11.85)

0.942

PLT (*10⁹/L)

319.00 [258.00, 405.50]

306.00 [256.00, 391.00]

336.00 [276.00, 422.00]

322.00 [252.00, 403.50]

0.214

CRP (mg/L)

72.00 [43.00, 104.50]

71.00 [41.00, 106.00]

67.00 [44.00, 100.00]

74.52 [46.79, 107.35]

0.478

ESR (mm/60min)

62.00 [46.00, 80.00]

62.00 [47.00, 81.00]

61.00 [43.00, 80.00]

61.00 [43.50, 81.50]

0.517

Na (mmol/L)

136.00 [133.00, 138.00]

135.00 [133.00, 138.00]

136.00 [133.50, 138.00]

135.00 [133.00, 137.00]

0.306

ALB (g/L)

34.70 [32.20, 37.10]

34.30 [31.80, 36.70]

34.70 [32.85, 37.25]

35.10 [32.50, 37.50]

0.11

Tbil (umol/L)

5.10 [3.70, 8.40]

5.10 [3.40, 8.70]

5.30 [3.95, 8.35]

5.40 [3.95, 7.15]

0.652

NT-proBNP (pg/ml)

602.70 [252.25, 1,444.00]

613.80 [253.10, 1,337.00]

553.60 [223.60, 1,202.50]

806.40 [315.80, 2,021.50]

0.281

PT (s)

12.20 [11.50, 12.90]

12.20 [11.50, 12.90]

12.10 [11.40, 12.85]

12.50 [11.60, 12.95]

0.302

FIB (g/L)

4.92 [4.38, 5.84]

4.96 [4.52, 5.85]

4.79 [4.30, 5.62]

5.34 [4.57, 6.04]

0.037

APTT (s)

30.30 [27.90, 33.00]

30.30 [27.90, 33.30]

30.00 [27.55, 32.50]

30.60 [28.55, 33.15]

0.359

D-Dimer (ug/L)

1.15 [0.65, 2.08]

1.16 [0.72, 2.07]

1.00 [0.56, 2.06]

1.20 [0.68, 2.25]

0.304

INR

1.06 [1.00, 1.13]

1.06 [1.00, 1.13]

1.05 [0.99, 1.12]

1.10 [1.01, 1.13]

0.258

FDP (ug/ml)

4.98 [3.20, 7.72]

5.10 [3.50, 7.70]

4.80 [2.90, 7.98]

4.69 [3.09, 6.90]

0.527

TT (s)

16.20 [15.50, 17.00]

16.10 [15.40, 17.10]

16.20 [15.50, 17.00]

16.00 [15.55, 16.75]

0.458

TNF-α (pg/ml)

18.00 [13.85, 24.95]

18.30 [13.30, 25.00]

16.60 [14.30, 22.70]

20.60 [14.70, 27.40]

0.188

IL-6 (pg/ml)

20.80 [7.58, 59.60]

20.70 [7.73, 68.40]

17.50 [6.12, 43.11]

39.20 [13.05, 57.10]

0.023

sIL-2R (pg/ml)

2,043.00 [1,346.00, 2,980.00]

2,062.00 [1,353.00, 3,452.00]

2,001.00 [1,326.00, 2,767.00]

2,047.00 [1,490.50, 3,065.00]

0.595

IL-8 (pg/ml)

19.70 [12.75, 37.45]

21.20 [13.70, 41.90]

17.90 [12.00, 31.65]

16.90 [11.70, 30.30]

0.101

IL-10 (pg/ml)

7.84 [2.50, 19.50]

8.58 [2.50, 21.00]

7.23 [2.50, 15.30]

6.90 [2.50, 23.80]

0.425