Table 6 Risk factors of a new reaction after VIT interruption; modified from [1]

Hypersensitivity to honeybee venom (less protection than vespid venom)

Serious systemic reaction prior to initiation of specific immunotherapy

Systemic reactions triggered by the administration of specific immunotherapy

Systemic reactions triggered by a puncture during specific immunotherapy

Allergy tests (skin tests and/or serum specific sIgE) with persistence of a high degree of sensitization in the fifth year of specific immunotherapy

Clonal mast cell disease