Table 4 Indications to prescription of adrenaline autoinjectors^b; modified from [1]

Children with previous systemic reaction or with large local reaction and high risk of re-stings (e.g., children of beekeepers), before immunotherapy

Children with high tryptase levels and a history of systemic Hymenoptera reactions, regardless of immunotherapy

Children undergoing immunotherapy who, in the maintenance or discontinuation phase, are still at risk of incomplete clinical protection (e.g., very serious reactions at onset, adverse reactions during immunotherapy, lack of protection demonstrated by new Hymenoptera stings during immunotherapy, severe honeybee allergy)

Patients with a history of large local reaction at risk of multiple stings (e.g., children of beekeepers)

Patients with a history of only one large local reaction, as the risk of more severe reactions in the event of a new sting cannot be excluded^a