Table 2 Stratified analysis of CNVs detection and pregnancy outcome in CL/P fetuses
Groups (Total cases) | CSVs | VUS | Live Births | TOPs | LTFU/Not LTFU |
|---|---|---|---|---|---|
Singleton vs. Twins (358) | |||||
 Singleton (338) | 26/338, 7.7% | 17/338, 5.0% | 191/338, 56.5% | 137/338, 40.5% | 10/338, 3.0% |
 Twins (20) | 3/20 15.0% | 1/20, 5.0% | 10/20, 50.0% | 8/20, 40.0% | 2/20, 10.0% |
 p-value | 0.433 | 1.000 | 0.569 | 0.068 | 0.140 |
Isolated vs. Non-isolateda (335) | |||||
 Isolated (305) | 15/305, 4.9% | 15/305, 4.9% | 188/305, 61.6% | 107/305, 35.1% | 10/305, 3.3% |
 Non-isolated (33) | 11/33, 33.3% | 2/33, 6.1% | 3/33, 9.1% | 30/33, 90.9% | 0/33 |
 p-value | 0.000 | 1.000 | 0.000 | 0.000 | / |
Affected relativesa (335) | |||||
 Yes (33) | 1/33, 3.0% | 1/33, 3.0% | 18/33, 54.5% | 15/33, 45.5% | 0/33 |
 No (305) | 25/305, 8.2% | 16/305, 5.2% | 173/305, 56.7% | 122/305, 40% | 10/305, 3.3% |
 p-value | 0.475 | 0.893 | 0.811 | 0.544 | / |
CP/CL vs. CLPa (335) | |||||
 CP (12) | 3/12, 25.0% | 1/12, 8.3% | 5/12, 41.7% | 7/12, 58.3% | 0/12 |
 CL (38) | 0/38 | 2/38, 5.3% | 32/38, 84.2% | 5/38, 13.2% | 1/38, 2.6% |
 CLP (288) | 23/288, 8.0% | 14/288, 4.9% | 155/288, 53.8% | 124/288, 43.1% | 9/288, 3.1% |
 p-value | / | 0.384 | 0.001 | 0.000 | / |